Laboratory Medicine Pathology Final

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UNIVERSITY OF TORONTO Faculty of Arts and Sciences APRIL 2011 EXAMINATIONS LMP301H1S DURATION: 2 HOURS Examination Aids: Non-programmable calculators are allowed

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SECTION I – MULTIPLE CHOICE (88 marks) The 44 questions are of equal value (2 marks). Select the most correct answer for each question. 1. Which of the following statements is TRUE regarding lipid biomarkers? i. ii. iii. iv. A. B. C. D. E. Total Cholesterol to HDL-C ratio is more sensitive for heart disease than cholesterol alone Elevated triglycerides are a defining criterion in metabolic syndrome Increase in lipoprotein(a) reflects accumulation of the small-dense form of LDL particles Measurement of Apo-A1 levels is useful in patients with metabolic syndrome at high risk i and ii i and iii iii and iv iv only All of the above (i, ii, iii and iv)

2. Which of the following statements is FALSE regarding regulation of body water? A. B. C. D. E. Receptors in the hypothalamus respond to increased osmolality and stimulate thirst As the effective circulating volume increases, aldosterone secretion is suppressed Congestive heart failure may arise from volume overload of the circulatory system Anti-diuretic hormone stimulates the Na+/K+ transporter to retain sodium and water Angiotensin II stimulates vasoconstriction and sodium resorption in the kidney

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3. Given the following test results: sodium potassium chloride bicarbonate glucose urea creatinine 146 mmol/L (135 - 147) 3.7 mmol/L (3.5 - 5.0) 100 mmol/L (96 - 108) 16 mmol/L (22 - 30) 4.1 mmol/L (4.0 - 6.0) 3.0 mmol/L (5.0 - 7.0) 110 µmol/L (60 - 120) osmolality ketones pH hydrogen ion PCO2 PO2 295 mOsm/kg (280 - 300) negative (negative) 7.45 (7.35 -7.45) 35 nmol/L (35 - 45) 25 mmHg (35 - 45) 75 mmHg (80 - 100)

Which of the following is the most likely explanation for a…...

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