Pharma Operations

In: Business and Management

Submitted By ankitnigam
Words 268
Pages 2
The manufacturing process of pharmaceutical industry usually have products in the forms such as tablets, which is a complex multi-stage process under which the starting materials change their physical characteristics a number of times before the final dosage form is produced.
Tablets have been made by granulation, a process that imparts two primary requisites to formulate: compactibility and fluidity. Both wet granulation and dry granulation (slugging and roll compaction) are used. Regardless of weather tablets are made by direct compression or granulation, the first step, milling and mixing, is the same; subsequent step differ.
Numerous unit processes are involved in making tablets, including particle size reduction and sizing, blending, granulation, drying, compaction, and (frequently) coating. Various factors associated with these processes can seriously affect content uniformity, bioavailability, or stability.

Figure.20. Various Unit Operation Sequences In Tablet Manufacturing

Figure.21. Typical Manufacturing Process Of Tablet
Table.22. Typical Unit Operation Involved In Wet Granulation, Dry Granulation And Direct Compression(13) WET GRANULATION | DRY GRANULATION | DIRECT COMPRESSION | 1.
Milling
and mixing of drugs and excipients | 1.
Milling
and mixing of drugs and excipients | 1. Milling and mixing of drugs and excipients | 2.
Preparation
of binder solution | 2.
Compression
into slugs or roll compaction | 2.
Compression of tablet | 3.
Wet
massing by addition of binder solution or granulating solvent | 3.
Milling
and screening of slugs and compacted powder | | 4.
Screening
of wet mass | 4.
Mixing
with lubricant and disintegrant | | 5.
Drying
of the wet granules | 5.
Compression
of tablet | | 6.
Screening
of dry granules | | | 7.
Blending
with lubricant and disintegrant to produce “running…...

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